mutation
noun
mu·ta·tion
myü-ˈtā-shən 
1
: a significant and basic alteration : change
2
: umlaut
3
a
: a relatively permanent change in hereditary material that involves either a change in chromosome structure or number (as in translocation, deletion, duplication, or polyploidy) or a change in the nucleotide sequence of a gene's codons (as in frameshift or missense errors) and that occurs either in germ cells or in somatic cells but with only those in germ cells being capable of perpetuation by sexual reproduction
Mutations known to cause disease have been identified in approximately 1000 genes.—
Alan E. Guttmacher and Francis S. Collins
Alan E. Guttmacher and Francis S. Collins
also
: the process of producing a mutation
Microorganisms have been used extensively to study mutation … —George A. Wistreich et al.
George A. Wistreich et al.
b
: an individual, strain, or trait resulting from mutation
The worst E. coli bacterium, E. coli 0157:H, a mutation discovered in 1982 that has at least sixty-two subtypes, causes hemorrhagic colitis …—Wayne Biddle
Wayne Biddle
mutationally
adverb
Examples of mutation in a Sentence
The cat's short tail is the result of mutation.
The condition is caused by a genetic mutation.
The building is a mutation of the original design.
Recent Examples on the Web
Rectal cancer tumors and colon cancer tumors usually originate from mutations that occur in polyps.
—Corey Whelan, Verywell Health, 15 Aug. 2024
California’s strongest summer COVID wave in years is still surging, and an unusual midsummer mutation may be partly to blame.
—Rong-Gong Lin Ii, Los Angeles Times, 12 Aug. 2024
Susannah Rosen, now 10 years old, has rare mutations in a gene called KIF1A, which is associated with intellectual disability, spastic limbs, and atrophy of nerve cells in the brain and eye.
—Brittany Trang, STAT, 9 Aug. 2024
The abbreviation for this mutation is F456L + R346T.
—Natalie Wallington, Kansas City Star, 18 July 2024
See all Example Sentences for mutation 
Corey Whelan, Verywell Health, 15 Aug. 2024
California’s strongest summer COVID wave in years is still surging, and an unusual midsummer mutation may be partly to blame.
—Rong-Gong Lin Ii, Los Angeles Times, 12 Aug. 2024
Susannah Rosen, now 10 years old, has rare mutations in a gene called KIF1A, which is associated with intellectual disability, spastic limbs, and atrophy of nerve cells in the brain and eye.
—Brittany Trang, STAT, 9 Aug. 2024
The abbreviation for this mutation is F456L + R346T.
—Natalie Wallington, Kansas City Star, 18 July 2024
See all Example Sentences for mutation
These examples are programmatically compiled from various online sources to illustrate current usage of the word 'mutation.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.
Dictionary Entries Near mutation
Cite this Entry
“Mutation.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/mutation. Accessed 17 Sep. 2024.
Copy CitationKids Definition
mutation
noun
mu·ta·tion
myü-ˈtā-shən
1
: a basic and important change
2
a
: a permanent change in hereditary material involving either a change in the position of the genes on the chromosomes or a basic change in the chemical structure of a gene
also
: the process of producing a mutation
b
: an individual, strain, or trait resulting from mutation
Medical Definition
mutation
noun
mu·ta·tion
myü-ˈtā-shən
1
: a relatively permanent change in hereditary material that involves either a change in chromosome structure or number (as in translocation, deletion, duplication, or polyploidy) or a change in the nucleotide sequence of a gene's codons (as in frameshift or missense errors) and occurs either in germ cells or in somatic cells but with only those in germ cells being capable of perpetuation by sexual reproduction
also
: the process of producing a mutation
2
: an individual, strain, or trait resulting from mutation
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